Serous cystadenoma of pancreas is mainly present in women, especially over the age of 60 years. Conclusion diffuse serous cystadenomas of the pancreas are extremely rare tumors. Serous cystadenomas were not established as an independent clinical or pathological cystadenoma until 1978 when the unique nonmucinous epithelial features. Laparoscopic pancreatic procedures are under evaluation. Serous cystic neoplasmtumor classificationtumor growth. A 55yearold female with left upper quadrant discomfort. Current perspectives on pancreatic serous cystic neoplasms. Comprising about 16% of all resected pancreatic cystic neoplasms. We report a case of incidentally detected pancreatic hc combined with a serous microcystic cystadenoma, in a 47yearold man, while he was being evaluated for renal calculi.
Mucinous cystadenoma constitutes approximately 23% of all the resected pancreatic cystic lesions, and serous cystadenoma accounts for 16%. The most remarkable descriptions of large ovarian cysts are those of spohn, who in 1922 reported one that weighed 148. Three women 71, 57 and 31 years old were admitted to hospital, two for diseases unrelated to the pancreas and the third for increasing obstructive jaundice in. Between january 1986 and october 1998 25 patients with serous cystic neoplasms of the pancreas were operated at our institution. Serous cystadenocarcinoma of the pancreas and serous cystadenoma associated with ductal pancreatic adenocarcinoma. Aggressive surgical resection with longterm followup may be worthwhile in this group of patients. The natural history and malignant potential of serous cystadenomas differ significantly from that of other cystic neoplasms. She had no past history of abdominal surgery, instrumentation, or trauma. Serous cystadenoma of pancreas radiology reference.
Cystic neoplasms of the pancreas are less common, accounting for about 1015% of all cystic pancreatic lesions. We report a case of solid type serous cystadenoma of the pancreas. This cystic neoplasm is made up of several small cysts spread into a honeycomb like appearance. Pancreatic serous cystadenoma is a benign tumour of pancreas.
Distal pancreatectomy was performed by laparotomy and. Author links open overlay panel riccardo pravisani a sergio giuseppe intini a rossano girometti b claudio avellini c cosimo alex leo a walter bugiantella d andrea risaliti a. Serous cystadenoma is a benign neoplasm composed of glycogenrich epithelial cells that form. However, in the discrimination of pancreatic serous cystadenoma and mucinous. Pancreatic hepatoid carcinoma hc is an extremely uncommon neoplasm of pancreas that resembles hepatocellular carcinoma hcc.
We report a case of a 45yearold man presenting with metastatic liver lesions on ultrasound. Although, they carry a realistic risk of malignancy despite the general view that they never become malignant. Serous cystadenoma of pancreas is a rare benign cystic neoplasm constituting 12% of all exocrine pancreatic tumors and isnt it 1015% of all cystic pancreatic neoplasms. We report a case, which, according to our best knowledge is the 27th case reported. Terms searched for were serous oligocystic adenoma and pancreas, macrocystic serous adenoma and pancreas, serous cystadenoma and pancreas, mucinous cys. How is benign mucinous cystadenoma of pancreas treated. There was no jaundice, loss of appetite, loss of weight or fever. Serous cystic neoplasms of the pancreas although they carry a realistic risk of malignancy, the predominant view is that they never become malignant. Diagnostic criteria, potential for growth or malignancy, and outcomes are not well defined.
Pancreatic serous cystadenomas report of 8 cases with a mean follow up of 7. We present a case of a 79yearold greek woman with symptomatic cholelithiasis and a serous pancreatic cystadenoma located at the neck of the pancreas. A case of macrocystic serous cystadenoma of the pancreas. Computed tomography of cystadenoma and cystadenocarcinoma. Accounts for almost 50% of pancreatic cystic neoplasms. Among benign, most common diagnoses were follicular luteal cysts 34. However, the tumor showed marked hyperintensity similar to that of hepatic cyst on mr cholangiopancreatography.
Serous cystadenoma of pancreas sca is a benign epithelial neoplasm of uncertain origin. B gross pathology photograph illustrates honeycomb pattern of microcysts and central fibrous scar. Serous adenomas represent 12% of pancreatic neoplasms and typically are asymptomatic not requiring any treatment and simple observation is the option of choice. Ten cases of cystadenoma or cystadenocarcinoma of the pancreas were examined by computed tomography ct. Frontiers discrimination of pancreatic serous cystadenomas.
Serous cystadenomas are the most common type of cystic neoplasm of the pancreas 5. Aug 25, 2017 serous cystadenoma of pancreas is a benign tumor of pancreas. Mucinous cystadenoma has considerable malignant potential, estimated to be between 10 and 50%. Unlike mucinous cystadenomas of the pancreas, serous cystic tumors are. The most common presentation is with numerous small cysts that give a honeycomb appearance microcystic variant, thin septa, and sometimes with a central scar. Approximately 40% of pancreatic serous cystadenoma arise from the pancreatic head and uncinate. Serous cystadenoma of the pancreas libre pathology. Macrocystic serous cystadenoma of the pancreas springerlink. The first case of metastatic serous cystadenocarcinoma was documented by george et al.
Serous cystadenoma of the pancreas is the most common benign pancreatic neoplasm. Computed tomographic and magnetic resonance mr images showed a hypervascular solid tumor that was difficult to differentiate from endocrine tumor of the pancreas. Extended operations are unnecessary for serous cystadenomas and minimally invasive surgery should be performed. Giant ovarian serous cystadenoma in a postmenopausal woman. Typically, a serous cystadenoma is morphologically classified as having either a polycystic, honeycomb, or oligocystic pattern. Serous cystic neoplasms of the pancreas 4 cm have malignant potential and therefore. Distal pancreatectomy was performed by laparotomy and histological and immunohistochemical. Once thought to be rare, cystic neoplasms of the pancreas are being diagnosed with increased frequency because of improvements in pancreatic imaging 14. Ct of serous cystadenoma of the pancreas and mimicking masses. Serous cystadenoma of the pancreas is a benign cystic lesion of the pancreas it is also known as serous microcystic adenoma, and pancreatic serous cystadenoma it is unrelated to the ovarian serous cystadenoma. Serous cystadenoma of pancreas is an uncommon benign tumor of the pancreas that forms as a cyst. Ovarian serous cystadenoma, also less precisely known as serous cystadenoma, is the most common ovarian neoplasm, representing 20% of ovarian neoplasms, and is benign it has a very superficial resemblance to the most common type of ovarian cancer serous carcinoma of the ovary under the microscope. Dec 16, 2019 mucinous cystadenoma constitutes approximately 23% of all the resected pancreatic cystic lesions, and serous cystadenoma accounts for 16%. She underwent transabdominal ultrasound us which showed well circumscribed lobulated echogenic mass in the pancreatic.
Although a lobulated contour is a specific feature of serous cystadenoma, it may be over looked on the initial ct evaluation fig. On magnetic resonance imaging, the cyst showed heterogeneous signal intensity on t1weighted images, and was. Serous cystadenoma of the pancreas, also referred as microcystic adenoma, is an uncommon type of benign cystic pancreatic neoplasm. Management of serous cystic adenoma of the pancreas medscape. Epidemiology there is a recognized strong female predilection m. The treatment measures available for benign mucinous cystadenoma of pancreas include the following. Giant ovarian serous cyst adenoma of such a huge size is a rare finding. Management of serous cystic adenoma of the pancreas.
Serous cystic neoplasms of the pancreas are usually benign. Serous cystadenoma of pancreas is a benign tumor of pancreas. Pdf management of serous cystadenoma of the pancreas. Serous cystadenoma of the pancreas with atypical clinical. In the differential diagnosis of pancreatic serous and mucinous cystadenomas, the combination of morphological. We report a case, which, according to our best knowledge is the 27th case reported in the literature. Imaging techniques have a low diagnostic power in terms of differentiation of masca from malignant lesions as mcns and bdipmn. Abdominal ultrasonography and an abdominal computed tomography revealed a multiloculated and calcified cyst in the body of the pancreas. It typically occurs in women most tumors do not cause any signs and symptoms, but in some individuals, there may be abdominal pain, indigestion, and loss of appetite due to serous cystadenoma of pancreas. Of the serous neoplasms, serous microcystic adenoma is the most common. We present a case of a 79yearold greek woman with symptomatic cholelithiasis and a serous pancreatic cystadenoma. Jul 14, 2017 serous cystadenoma of pancreas is a benign tumor of pancreas. While serous cystadenomas are almost uniformly benign, mucinous cystic tumors all have malignant potential and must be treated as such. A t1weighted image, using magnetic resonance imaging.
As a result, management for patients with serous cystadenomas varies widely in current practice. In contrast to some of the other cystforming tumors of the pancreas such as the intraductal papillary mucinous neoplasm and the mucinous cystic neoplasm, serous cystic neoplasms are almost always entirely benign. Herein, we report a case of a solidtype serous cystadenoma of the pancreas which is the 16th case reported worldwide and the first ever reported in greece. Malignant serous cystic neoplasm is a rare clinical entity.
They can be divided into serous and mucinous subtypes, with the former behaving less aggressively and generally considered benign. Epidemiology, diagnosis, and management of cystic lesions of the pancreas epidemiology, diagnosis, and management of cystic lesions of the pancreas. The pancreatic serous cystadenoma is an epithelial neoplasm that mostly affects women with a slight predominance in the pancreatic head. Among this group of lesions, the serous cystadenoma is typically asymptomatic.
Serous cystadenocarcinoma of the pancreas and serous. Laparoscopic resection of a pancreatic serous cystadenoma. Computed tomography of cystadenoma and cystadenocarcinoma of. An extremely rare solid variant of serous microcystic adenoma lacking secretory capability. In contrast, serous cystadenoma is considered benign and are typically found incidentally. Differential diagnosis of pancreatic serous cystadenoma. Hepatoid carcinoma of the pancreas combined with serous. A 35yrold woman presented with mild upper abdominal pain. The most common cystic lesions of the pancreas seen on imaging are pseudocysts, serous cystadenoma, mucincontaining lesions ipmn, mucinous. Typical and atypical manifestations of serous cystadenoma. If you do not see its contents the file may be temporarily unavailable at the journal website or you do not have a pdf plugin installed and enabled in your browser. We report a 47yearold woman with macrocystic serous cystadenoma of the pancreas. Ultrasonography and computed tomography revealed a unilocular cyst in the body of the pancreas. Serous cystadenoma article about serous cystadenoma by.
Cystic neoplasms of the pancreas are less common than solid tumors, and portend a better prognosis. In all, 106 patients diagnosed with serous cystadenoma were identified. Magnetic resonance imaging showed a hypervascular mass in the tail of the pancreas of a 72yearold female who presented with mild abdominal pain. The chart showing pdf series, word series, html series, scan qr codes. Clinical features and natural history of serous cystic neoplasm of. Methods fiftythree patients with pancreatic serous cystadenoma and 25 patients with pancreatic mucinous cystadenoma were included. Serous cystic neoplasms scns of the pancreas are almost always benign, and are among the common primary pancreatic. May 11, 2018 how is benign mucinous cystadenoma of pancreas treated. Serous cystadenoma article about serous cystadenoma by the free dictionary. Transverse image a shows a complex mass in the body of the pancreas, composed of multiple, small cysts, separated by an echogenic, fibrous scar arrows and with increased posterior acoustic enhancement. In the clinical practise of masca, surgery appears to gain indications that are wider than those correlated to the pathologic outcome, because of the necessity of a correct differential diagnosis from potentially malignant cystic tumors and the frequent. Serous cystadenoma microcystic type on transabdominal ultrasound. Jul 16, 2009 pancreatic serous cystadenomas are rare benign cystic neoplasms. This is the first case of a macrocystic serous cystadenocarcinoma of the pancreas, highlighting the need for extensive sampling of all cystic lesions of the pancreas in order to reach a correct.
Postoperative pathological evaluation is of particular importance for distinguishing solid sca of the pancreas from other pancreatic solid tumors. Atypical manifestations of serous cystadenoma can include giant tumors with ductal dilatation, intratumoral hemorrhages, solid variants, unilocular cystic tumors, interval growth, and a disseminated form. Diffuse pancreatic serous cystadenoma associated with. Discrimination of pancreatic serous cystadenomas from. Intraductal papillary mucinous neoplasm ipmn, serous. Any information contained in this pdf file is automatically generated from digital material. Innumerable small cysts producing a honeycomb appearance were noticed in serous cystadenomas. Serous cystadenoma article about serous cystadenoma by the. If there are no signs and symptoms, then a wait and watch approach has been recommended by some experts, since it is a benign condition.
Serous cystadenoma is more common than mucinous cystic neoplasm, with a ratio of about 2. Small cystic spaces lined by small cuboidal cells with clear cytoplasm glycogen, minimal mucin, myoepithelial layer present, round hyperchromatic central nuclei. Three cases of pancreatic serous cystadenoma and endocrine. Lined by flattened or cuboidal cells that contain glycogen and little or no mucin. Solid serous cystadenoma sca of the pancreas is a rare type of pancreatic solid tumors. Radiologic and pathologic correlation poster no c1026. Jan, 2019 serous cystadenoma of pancreas is an uncommon benign tumor of the pancreas that forms as a cyst.
Pancreatic serous cystadenoma is a benign neoplasm. Jun 12, 2019 the lesions of half of the patients with mucinous cystadenoma were located in the head of pancreas and the lesions of other patients were located in the body or the tail of pancreas. Serous cystic neoplasmtumor classification tumor growth. Tumor growth rates and recommendations for treatment. This question refers to a serous cystic serocystic adenoma often referred to as a microcystic adenoma of the pancreas. Serous cystadenocarcinoma of the pancreas presenting with.
To date, only approximately 30 cases of serous cystadenocarcinoma are reported in the literature7. Solid serous microcystic adenoma of the pancreas world. Three of the 25 tumours 12% showed a malignant behaviour on histological assessment, whereas two patients with serous cystadenoma 8% revealed an association with ductal adenocarcinoma. Serous cystadenoma definition of serous cystadenoma by. Management of pancreatic serous cystadenomas advances in.
A benign cystic tumor of the ovary, made up of cylindrical cells resembling those of the uterine tube. Ct of serous cystadenoma of the pancreas and mimicking. In contrast to some of the other cystforming tumors of the pancreas such as the intraductal papillary mucinous neoplasm and the mucinous cystic neoplasm, serous cystic neoplasms are almost always. Usually it does not produce any symptoms and if present, they are abdominal pain, appetite loss and indigestion. All but one showed characteristic findings consisting of both cystic and solid components. Serous cystadenocarcinoma of the pancreas request pdf. Apr 06, 2017 cystic neoplasms of the pancreas are less common, accounting for about 1015% of all cystic pancreatic lesions. Differential diagnosis of pancreatic serous cystadenoma and. Serous cystadenoma of pancreas radiology reference article. The two most common cystic neoplasms of the pancreas are serous cystadenoma and mucinous cystic neoplasms. Serous cystadenoma definition of serous cystadenoma by the. Serous cystadenoma of the pancreas is commonly considered to be a benign neoplasm and therefore a more conservative. Pancreatic serous cystadenomas are rare benign cystic neoplasms. Objectives this study was designed to estimate the performance of textural features derived from contrastenhanced ct in the differential diagnosis of pancreatic serous cystadenomas and pancreatic mucinous cystadenomas.
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